Plasticizer Bis(2-ethylhexyl) Phthalate Causes Meiosis Defects and Decreases Fertilization Ability of Mouse Oocytes in Vivo
Z Lu, C Zhang, C Han, Q An, Y Cheng… - Journal of agricultural …, 2019 - ACS Publications
Bis (2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer in polyvinyl chloride (PVC)
plastics. Humans and animals are widely and continuously exposed to DEHP, especially
with respect to diet, which is associated with reproductive diseases. Nevertheless, the effects
and underlying mechanisms of DEHP exposure on oocytes in vivo remain ambiguous. In
this study, we found that oral administration of DEHP (40 μg/kg body weight per day for 14
days) markedly reduced the maturation and fertilization of oocytes in vivo. In addition, DEHP …
plastics. Humans and animals are widely and continuously exposed to DEHP, especially
with respect to diet, which is associated with reproductive diseases. Nevertheless, the effects
and underlying mechanisms of DEHP exposure on oocytes in vivo remain ambiguous. In
this study, we found that oral administration of DEHP (40 μg/kg body weight per day for 14
days) markedly reduced the maturation and fertilization of oocytes in vivo. In addition, DEHP …
Plasticizer bis(2-ethylhexyl) phthalate causes meiosis defects and decreases fertilization ability of mouse oocytes in vivo.
LZZ Lu ZhenZhen, ZCT Zhang ChengTu… - 2019 - cabidigitallibrary.org
Abstract Bis (2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer in polyvinyl chloride
(PVC) plastics. Humans and animals are widely and continuously exposed to DEHP,
especially with respect to diet, which is associated with reproductive diseases. Nevertheless,
the effects and underlying mechanisms of DEHP exposure on oocytes in vivo remain
ambiguous. In this study, we found that oral administration of DEHP (40 µg/kg body weight
per day for 14 days) markedly reduced the maturation and fertilization of oocytes in vivo. In …
(PVC) plastics. Humans and animals are widely and continuously exposed to DEHP,
especially with respect to diet, which is associated with reproductive diseases. Nevertheless,
the effects and underlying mechanisms of DEHP exposure on oocytes in vivo remain
ambiguous. In this study, we found that oral administration of DEHP (40 µg/kg body weight
per day for 14 days) markedly reduced the maturation and fertilization of oocytes in vivo. In …
以上显示的是最相近的搜索结果。 查看全部搜索结果