… To assess whether dysregulated autophagy causes the accumulation of synaptic vesicles
at … the autophagic flux in Plekhg5-deficient motoneurons (Fig. 5). Since autophagosomes …

… dysregulated autophagy causes the accumulation of synaptic vesicles at nerve terminals
we … the autophagic flux in Plekhg5-deficient motoneurons (Fig. 5). Since autophagosomes …

… Here we show that the lower motoneuron disease-associated guanine … mediates the
autophagy of synaptic vesicles by Rab26 17 . … This approach revealed that the majority of Sod1 …

… -onset motoneuron disease caused by impaired autophagy-mediated clearance of synaptic
vesicles … Morphometric analysis revealed a significantly reduced axonal diameter in Plekhg5-…

… autophagosomes, we could show that Plekhg5-regulated Sod1 secretion is … Plekhg5-regulated
autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. …

… Other pathogenic processes that can impair autophagy and/… the autophagy process at
synapses and for synaptic vesicle … the mechanisms underlying defects in autophagy at synapses …

Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in
motoneuron disease. … Plekhg5-regulated autophagy of synaptic vesicles reveals a …

… Cultured motor neurons with reduced Plekhg5, the GEF for … axon outgrowth and impaired
autophagy of synaptic vesicles [56]… models has revealed differing effects of autophagy on axon …

… autophagy is a crucial regulator of PKA signaling at synapses… ATG5-deficient neurons reveal
an accumulation of synapse-… synaptic plasticity, among other mechanisms. Indeed, loss of …

… pathogenesis 5 and the efficacy of therapeutic agents 6 . … , that autophagy-mediated
clearance of synaptic vesicles is … Our results reveal a prominent regulatory function of PLEKHG5 …