Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-β signaling.
Axon pruning during development is essential for the proper wiring of the mature nervous
system, but its regulation remains poorly understood. We have identified an immunoglobulin
superfamily (IgSF) transmembrane protein, Plum, that is cell-autonomously required for axon
pruning of mushroom body (MB) γ neurons and for ectopic synapse refinement at the
developing neuromuscular junction in Drosophila. Plum promotes MB γ neuron axon
pruning by regulating the expression of Ecdysone Receptor-B1, a key initiator of axon …
system, but its regulation remains poorly understood. We have identified an immunoglobulin
superfamily (IgSF) transmembrane protein, Plum, that is cell-autonomously required for axon
pruning of mushroom body (MB) γ neurons and for ectopic synapse refinement at the
developing neuromuscular junction in Drosophila. Plum promotes MB γ neuron axon
pruning by regulating the expression of Ecdysone Receptor-B1, a key initiator of axon …
Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-β signaling
Axon pruning during development is essential for proper wiring of the mature nervous
system, but its regulation remains poorly understood. We have identified an immunoglobulin
superfamily (IgSF) transmembrane protein, Plum, that is cell autonomously required for axon
pruning of mushroom body (MB) γ neurons and for ectopic synapse refinement at the
developing neuromuscular junction in Drosophila. Plum promotes MB γ neuron axon
pruning by regulating the expression of Ecdysone Receptor-B1, a key initiator of axon …
system, but its regulation remains poorly understood. We have identified an immunoglobulin
superfamily (IgSF) transmembrane protein, Plum, that is cell autonomously required for axon
pruning of mushroom body (MB) γ neurons and for ectopic synapse refinement at the
developing neuromuscular junction in Drosophila. Plum promotes MB γ neuron axon
pruning by regulating the expression of Ecdysone Receptor-B1, a key initiator of axon …