Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions
M Mompeán, V Romano, D Pantoja-Uceda… - Journal of Biological …, 2017 - ASBMB
Transactive response DNA-binding protein 43 (TDP-43) performs multiple tasks in mRNA
processing, transport, and translational regulation, but it also forms aggregates implicated in
amyotrophic lateral sclerosis. TDP-43's N-terminal domain (NTD) is important for these
activities and dysfunctions; however, there is an open debate about whether or not it adopts
a specifically folded, stable structure. Here, we studied NTD mutations designed to
destabilize its structure utilizing NMR and fluorescence spectroscopies, analytical …
processing, transport, and translational regulation, but it also forms aggregates implicated in
amyotrophic lateral sclerosis. TDP-43's N-terminal domain (NTD) is important for these
activities and dysfunctions; however, there is an open debate about whether or not it adopts
a specifically folded, stable structure. Here, we studied NTD mutations designed to
destabilize its structure utilizing NMR and fluorescence spectroscopies, analytical …
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