Polymer topology driven enzymatic biodegradation in polycaprolactone block and random copolymer architectures for drug delivery to cancer cells

M Malhotra, B Surnar, M Jayakannan - Macromolecules, 2016 - ACS Publications
… reports polymer topology design principle for programming the enzymatic biodegradation
and … goal, new classes of biodegradable amphiphilic block and random copolymers based on …

Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications

Z Li, BH Tan - Materials Science and Engineering: C, 2014 - Elsevier
… clinical use; biodegradability by enzyme and hydrolysis under … of the copolymer and the
topological variation of the triblock … block copolymers with higher degrees of polymerization than …

Perylene-tagged polycaprolactone block copolymers and their enzyme-biodegradable fluorescent nanoassemblies for intracellular bio-imaging in cancer cells

B Kulkarni, M Malhotra… - ACS Applied Polymer …, 2019 - ACS Publications
blocks are designed with biodegradable aliphatic polyester chains (PCL chains); hence,
they can be readily enzymatically biodegraded by intracellular enzymes … Stability of polymer

Polycaprolactone: a biodegradable polymer with its application in the field of self-assembly study

P Mandal, R Shunmugam - Journal of Macromolecular Science …, 2020 - Taylor & Francis
… star block copolymers of polycaprolactone backbone … topology controlled enzymatic
biodegradation was investigated by varying the carboxylic acid segments. The random copolymers

Structural engineering of star block biodegradable polymer unimolecular micelles for drug delivery in cancer cells

U Pranav, M Malhotra, S Pathan… - … Biomaterials Science & …, 2022 - ACS Publications
… engineering of biodegradable star block polycaprolactone (PCL) to … to trace the role of the
macromolecular topology in the … Slow enzymatically biodegradable PCL segments at the core …

Effect of in vitro enzymatic degradation on 3D printed poly (ε-caprolactone) scaffolds: Morphological, chemical and mechanical properties

J Ferreira, A Gloria, S Cometa… - Journal of applied …, 2017 - journals.sagepub.com
Biodegradable Solid polymeric devices which break down to macromolecule degradation
… Seven specimens of each scaffold topology, after being sterilized with UV radiation for 30 …

Synthesis, Characterization and Application of Polycaprolactone Based Systems

G Damonte - 2024 - tesidottorato.depositolegale.it
… the use of polymers characterized by star molecular topology, … This work aimed to develop
novel biodegradable PCL-based … combined with the action of enzymes such as esterases and …

Hydrolytic and microbial degradation of multi-block polyurethanes based on poly (ɛ-caprolactone)/poly (ethylene glycol) segments

S Cometa, I Bartolozzi, A Corti, F Chiellini… - Polymer Degradation …, 2010 - Elsevier
… hydrophilic and highly flexible polymer, not biodegradable but able to be eliminated … enzymes.
However, crystallinity and high molecular weight of the polymer may hinder the enzymatic

Polymer Topology Driven Enzymatic Biodegradation in Polycaprolactone Block and Random Copolymer Architectures for Drug Delivery to Cancer Cells

B Surnar, M JAYAKANNAN, M Malhotra - 2016 - dr.iiserpune.ac.in
… reports polymer topology design principle for programming the enzymatic biodegradation
and … goal, new classes of biodegradable amphiphilic block and random copolymers based on …

Synthesis of E-caprolactone based antimicrobial biodegradable scaffolds

FB Mamba - 2019 - scholar.sun.ac.za
… , polycaprolactone was synthesized and antimicrobial agents were attached to the polymer
… Candida antarctica lipase is a common enzyme that is used for enzymatic polymerization. …