Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: a Mendelian randomization meta-analysis
A Ioannidis, E Ikonomi, NL Dimou, L Douma… - Molecular genetics and …, 2010 - Elsevier
Polycystic ovary syndrome (PCOS) is a heterogeneous condition with unknown aetiology
which is considered to be the most common endocrine disorder in women of reproductive
age. In this work we investigated the association of insulin receptor (ΙNSR) and insulin
receptor substrates (IRSs) polymorphisms with the risk of developing PCOS. The meta-
analysis of eleven studies (889 cases, 1303 controls) yielded a significant association for
IRS-1 Gly972Arg (G972R) polymorphism concerning the GR vs. GG genotype (OR: 1.77 …
which is considered to be the most common endocrine disorder in women of reproductive
age. In this work we investigated the association of insulin receptor (ΙNSR) and insulin
receptor substrates (IRSs) polymorphisms with the risk of developing PCOS. The meta-
analysis of eleven studies (889 cases, 1303 controls) yielded a significant association for
IRS-1 Gly972Arg (G972R) polymorphism concerning the GR vs. GG genotype (OR: 1.77 …
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