The coating of polypeptidic micelles with sodium alginate is described as a strategy to
improve the stability of micelles for drug delivery. Bedaquiline, approved in 2012 for the
treatment of multidrug resistant tuberculosis, has been used as an example of hydrophobic
drug to study the loading efficiency, the release of the encapsulated drug in different media,
and the in vitro antimicrobial activity of the system. Alginate coating prevents the burst
release of the drug from micelles upon dilution and leads to a sustained release in all tested …

… Synthesis process and schematic representation of the empty micelles formed by the block
copolymers ZK30-b-En. … Synthesis process and schematic representation for the encapsulation
process of BQ in micelles of ZK30-b-En for screening of BQ/ZK30-b-En weight ratio (R): 0.16 ≤
R ≤ 0.60. … SEM micrographs of BQ-loaded alginate coated particles using 20 % wt alginate
BQ-M30-L (left and center). Histogram obtained from SEM images of BQ-M30-L (right). …