Poor sensitivity of fecal gluten immunogenic peptides and serum antibodies to detect duodenal mucosal damage in celiac disease monitoring
A lifelong gluten-free diet (GFD) is the only current treatment for celiac disease (CD), but
strict compliance is complicated. Duodenal biopsies are the “gold standard” method for
diagnosing CD, but they are not generally recommended for disease monitoring. We
evaluated the sensitivity and specificity of fecal gluten immunogenic peptides (GIPs) to
detect duodenal lesions in CD patients on a GFD and compared them with serum anti-tissue
transglutaminase (tTG) IgA antibodies. A prospective study was conducted at two tertiary …
strict compliance is complicated. Duodenal biopsies are the “gold standard” method for
diagnosing CD, but they are not generally recommended for disease monitoring. We
evaluated the sensitivity and specificity of fecal gluten immunogenic peptides (GIPs) to
detect duodenal lesions in CD patients on a GFD and compared them with serum anti-tissue
transglutaminase (tTG) IgA antibodies. A prospective study was conducted at two tertiary …