Thus, ZNF804A is very likely a true susceptibility locus for schizophrenia, albeit one that confers a small increment in risk. 1, 2 We examined rs1344706 within two independent samples of Han Chinese populations: a population-based sample and a familybased sample. Our results provide further evidence for a positive association between the ZNF804A locus and schizophrenia.

The study was approved by the local psychiatry research ethics committees and informed consent was obtained from all subjects. The population-based sample included 566 schizophrenics (295 males, mean age= 35.2±11.9; 271 females, mean age= 32.6±13.7) and 574 healthy control subjects (329 males, mean age= 29.0±14.1; 245 females, mean age= 29.3±13.5). The family-based sample consisted of 101 schizophrenia probands and their biological parents. The probands included 39 males (mean age= 25.3±7.5) and 62 females (mean age= 22.2±6.8). All patients were diagnosed by the psychiatrists of the First Affiliated Hospital of Xi’an Jiaotong University School of Medicine according to Diagnostic and