… Since the functional annotations are moderately correlated with the 8 continuous-… that causal
disease effect sizes are more population-specific in functionally important regions impacted …

… regions impacted by selection and 369 stronger G¢E interaction in functionally important
regions … a challenge, because functionally important regions are more strongly impacted 371 by …

… population-specific PIPs for each variant in a credible set), while allowing them to have varying
effect sizes (including null effects) … among mutations of functional importance. In total, we …

… (including population-specific SNPs), and/or causal effect size … ,30 ; functional annotations
impacted prior causal probabilities … the HLA region and two other long-range LD regions from …

… effect size distribution of each variant in the two populations to be null, population-specific or
… informed statistical fine-mapping to identify and prioritize functional variants, whose effects …

… by applying SuSiE 26 with functionally informed priors, which … differences in causal allele
frequencies, causal effect sizes, … explained by shared and population specific effects, we used …

… ancestry, we demonstrate that estimated causal effect sizes are highly similar across these
… Population-specific causal disease effect sizes in functionally important regions impacted by …

… it is indistinguishable which trait causally impacts fitness, although a … If 10% of the genome
is of any functional importance, and trait… have population-specific effect sizes. Such studies are …

… Second, functionally important regions of the genome should … increased causal effect
sizes, as the maximum effect size is … regions of the genome have been under population-specific …

… We found that effect sizes of eQTLs were negatively … Regardless of the proportion of the
human genome that is functional,… have a large effect on gene expression (A) Population-specific …