This review addresses important issues of porcine reproductive and respiratory syndrome
virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most
economically important infectious disease of pigs. We highlight the latest information on viral
genome structure, pathogenic mechanisms, and host immunity, with a special focus on
immune factors that modulate PRRSV infections during the acute and chronic/persistent
disease phases. We address genetic control of host resistance and probe effects of PRRSV …