Lack of potable water is an important problem of global dimensions. In Mexico, the northern and central regions have significant shortages, a situation which is exacerbated by the pollution of aquifers. Several studies have reported controversial results on high concentrations of heavy metals and halogens in aquifers in the state of Aguascalientes. Poor water quality is caused by the geological conditions in the region, water over-exploitation, and inadequate disposal of industrial waste. However, human exposure to these xenobiotics and their associated toxicological impact has received minimal attention. Many of these contaminants are nephrotoxic agents and this condition is aggravated when they mix.