Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models
M Takeshita, H Fukuyama, K Kamada, T Matsumoto… - Iscience, 2022 - cell.com
The use of therapeutic neutralizing antibodies against SARS-CoV-2 infection has been
highly effective. However, there remain few practical antibodies against viruses that are
acquiring mutations. In this study, we created 494 monoclonal antibodies from patients with
COVID-19-convalescent, and identified antibodies that exhibited the comparable
neutralizing ability to clinically used antibodies in the neutralization assay using pseudovirus
and authentic virus including variants of concerns. These antibodies have different profiles …
highly effective. However, there remain few practical antibodies against viruses that are
acquiring mutations. In this study, we created 494 monoclonal antibodies from patients with
COVID-19-convalescent, and identified antibodies that exhibited the comparable
neutralizing ability to clinically used antibodies in the neutralization assay using pseudovirus
and authentic virus including variants of concerns. These antibodies have different profiles …
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