The paper examines Buruli ulcer and its poverty and socio-economic ramifications in the Ga West District of Ghana. Although the disease has received public health attention, its impact on individuals, families and communities has not been given critical attention. The study found Buruli ulcer to be associated with deprived areas where poor socio-economic and infrastructural conditions are manifested in the lack of employable skills and low incomes. Also associated with the disease are those activities that interfere with the environment and make it a habitat for disease causing organisms. The study recommends good environmental management, improved water sources, early detection and treatment, and education, as the best measures to reduce morbidity and costs in the management of the disease.