Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines
A Link, S Van Calenbergh, P Herdewijn - Tetrahedron letters, 1998 - Elsevier
A new synthetic strategy for the simple and high yielding preparation of arrays of 2′-amido-
2′-deoxyadenosine derivatives ready for biological testing without the need for
chromatographic purification is described. Acids are coupled to the Kenner or Ellman safety
catch linker, respectively, activated by cyanomethylation and subsequently transferred to the
2′-amino group of 2′-amino-2′-deoxyadenosine.
2′-deoxyadenosine derivatives ready for biological testing without the need for
chromatographic purification is described. Acids are coupled to the Kenner or Ellman safety
catch linker, respectively, activated by cyanomethylation and subsequently transferred to the
2′-amino group of 2′-amino-2′-deoxyadenosine.
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