Pre-treatment T-cell subsets associate with fingolimod treatment responsiveness in multiple sclerosis
Biomarkers predicting fingolimod (FTY) treatment response in relapsing-remitting multiple
sclerosis (RRMS) are lacking. Here, we performed extensive functional immunophenotyping
using multiparametric flow cytometry to examine peripheral immune changes under FTY
treatment and explore biomarkers of FTY treatment response. From among 135 RRMS
patients who initiated FTY in a 2-year multicentre observational study, 36 were classified as
'Active'or 'Stable'based on clinical and/or radiological activity on-treatment. Flow cytometric …
sclerosis (RRMS) are lacking. Here, we performed extensive functional immunophenotyping
using multiparametric flow cytometry to examine peripheral immune changes under FTY
treatment and explore biomarkers of FTY treatment response. From among 135 RRMS
patients who initiated FTY in a 2-year multicentre observational study, 36 were classified as
'Active'or 'Stable'based on clinical and/or radiological activity on-treatment. Flow cytometric …
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