Preclinical assessment of young blood plasma for Alzheimer disease
Importance Alzheimer disease (AD) pathology starts long before clinical symptoms manifest,
and there is no therapy to treat, delay, or prevent the disease. A shared blood circulation
between 2 mice (aka parabiosis) or repeated injections of young blood plasma (plasma from
2-to 3-month-old mice) into old mice has revealed benefits of young plasma on synaptic
function and behavior. However, to our knowledge, the potential benefit of young blood has
not been tested in preclinical models of neurodegeneration or AD. Objectives To determine …
and there is no therapy to treat, delay, or prevent the disease. A shared blood circulation
between 2 mice (aka parabiosis) or repeated injections of young blood plasma (plasma from
2-to 3-month-old mice) into old mice has revealed benefits of young plasma on synaptic
function and behavior. However, to our knowledge, the potential benefit of young blood has
not been tested in preclinical models of neurodegeneration or AD. Objectives To determine …
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