Precocious myelination in a mouse model of autism
M Khanbabaei, E Hughes, J Ellegood, LR Qiu… - Translational …, 2019 - nature.com
Autism spectrum disorder (ASD) has been hypothesized to be a result of altered connectivity
in the brain. Recent imaging studies suggest accelerated maturation of the white matter in
young children with ASD, with underlying mechanisms unknown. Myelin is an integral part of
the white matter and critical for connectivity; however, its role in ASD remains largely
unclear. Here, we investigated myelin development in a model of idiopathic ASD, the BTBR
mice. Magnetic resonance imaging revealed that fiber tracts in the frontal brain of the BTBR …
in the brain. Recent imaging studies suggest accelerated maturation of the white matter in
young children with ASD, with underlying mechanisms unknown. Myelin is an integral part of
the white matter and critical for connectivity; however, its role in ASD remains largely
unclear. Here, we investigated myelin development in a model of idiopathic ASD, the BTBR
mice. Magnetic resonance imaging revealed that fiber tracts in the frontal brain of the BTBR …
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