The extrusion process is a very complex process due to the number of process parameters that are associated with it which are prone to high fluctuations. The main purpose of this work is to determine the realistic extrusion process parameters in the thermoplastic extrusion process in Nigeria cable manufacturing industries with the use of an artificial neural network. Conventionally, the use of trial and error technique which involves full-size experiments is generally used to determine the process parameters in the thermoplastic extrusion process. This conventional technique is expensive and it is also time-consuming. The use of an artificial neural network to predict extrusion process parameters before plant execution will make extrusion process operations more efficient. This technique also bridges the gap that exists between theoretical analysis and real manufacturing system because real manufacturers' data was used. The neural network was developed in a MATLAB environment and was trained with a supervised learning method based on Levenberg Marquardt Algorithm and the developed ANN model is capable of predicting manufacturing process parameters for different grades of PVC thermoplastic material.