Background Coiled-coils are described as stable structural motifs, where two or more
helices wind around each other. However, coiled-coils are associated with local mobility and
intrinsic disorder. Intrinsically disordered regions in proteins are characterized by lack of
stable secondary and tertiary structure under physiological conditions in vitro. They are
increasingly recognized as important for protein function. However, characterizing their
behaviour in solution and determining precisely the extent of disorder of a protein region …

Coiled-coils are described as stable structural motifs, where two or more helices wind
around each 15 other. However, coiled-coils are associated with local mobility and intrinsic
disorder. Intrinsically 16 disordered regions (IDRs) in proteins are characterized by lack of
stable secondary and tertiary 17 structure under physiological conditions in vitro. They are
increasingly recognized as important for 18 protein function. However, characterizing their
behaviour in solution and determining precisely the 19 extent of disorder of a protein region …