Prediction of lateral pelvic lymph node metastasis in patients with locally advanced rectal cancer with preoperative chemoradiotherapy: focus on MR imaging findings
PloS one, 2018•journals.plos.org
Purpose To investigate the predictive factors for lateral pelvic lymph node (LPLN) metastasis
in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy
(CRT). Materials and methods Fifty-seven patients with locally advanced rectal cancer and
LPLNs larger than 5 mm underwent LPLN dissection (LPLD) after preoperative CRT. The
MRI findings, including the apparent diffusion coefficient value and LPLN size reduction rate
before/after CRT; clinical factors; and pathologic results were evaluated to identify the …
in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy
(CRT). Materials and methods Fifty-seven patients with locally advanced rectal cancer and
LPLNs larger than 5 mm underwent LPLN dissection (LPLD) after preoperative CRT. The
MRI findings, including the apparent diffusion coefficient value and LPLN size reduction rate
before/after CRT; clinical factors; and pathologic results were evaluated to identify the …
Purpose
To investigate the predictive factors for lateral pelvic lymph node (LPLN) metastasis in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy (CRT).
Materials and methods
Fifty-seven patients with locally advanced rectal cancer and LPLNs larger than 5 mm underwent LPLN dissection (LPLD) after preoperative CRT. The MRI findings, including the apparent diffusion coefficient value and LPLN size reduction rate before/after CRT; clinical factors; and pathologic results were evaluated to identify the predictive factors associated with LPLN metastasis.
Results
LPLN metastasis was confirmed in 23 patients (40.4%). Metastasis was significantly higher in LPLNs with multiplicity, short-axis diameter ≥8 mm before CRT, short-axis diameter >5 mm after CRT, size reduction rate ≤33.3%, heterogeneous signal intensity, and irregular margin (P<0.05) on MR. Multivariable analysis showed that pre-CRT short-axis diameter of LPLNs ≥8 mm, size reduction rate ≤33.3%, and heterogeneous signal intensity were independently associated with LPLN metastasis.
Conclusions
The size and signal intensity of LPLN before and after CRT are useful MRI findings to predict LPLN metastasis and are helpful to determine the indications for LPLD.
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