Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera
JO Ngwuta, M Chen, K Modjarrad, MG Joyce… - Science translational …, 2015 - science.org
Respiratory syncytial virus (RSV) is estimated to claim more lives among infants< 1 year old
than any other single pathogen, except malaria, and poses a substantial global health
burden. Viral entry is mediated by a type I fusion glycoprotein (F) that transitions from a
metastable prefusion (pre-F) to a stable postfusion (post-F) trimer. A highly neutralization-
sensitive epitope, antigenic site Ø, is found only on pre-F. We determined what fraction of
neutralizing (NT) activity in human sera is dependent on antibodies specific for antigenic site …
than any other single pathogen, except malaria, and poses a substantial global health
burden. Viral entry is mediated by a type I fusion glycoprotein (F) that transitions from a
metastable prefusion (pre-F) to a stable postfusion (post-F) trimer. A highly neutralization-
sensitive epitope, antigenic site Ø, is found only on pre-F. We determined what fraction of
neutralizing (NT) activity in human sera is dependent on antibodies specific for antigenic site …
[引用][C] Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera. Sci Transl Med 7: 309ra162
JO Ngwuta, M Chen, K Modjarrad, MG Joyce… - 2015
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