Silicone materials have been investigated widely in broad fields for their versatile and excellent structure and performance. With highly selective and simple orthogonal reactions that do not yield side products and give heteroatom-linked molecular systems with high efficiency under a variety of mild conditions, click chemistry is of great interest in novel material research. The current review is made of the recent research progress in preparation and modification of silicone materials by means of click chemistry, and especially, it introduces the synthesis of polysiloxane based amphiphilic polymer and elastomer and functionalization of polysiloxane. In addition, the applications of these silicone materials in fields of biomedical materials and photoelectric materials are summarized. Finally, we present the trend and future prospects of novel silicone materials based on click chemistry.