Prepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings

JK Wynn, ME Dawson, AM Schell, M McGee… - Biological …, 2004 - Elsevier
BACKGROUND: Deficits in schizophrenia patients and their first-degree relatives have been
reported in prepulse inhibition (PPI), a phenomenon that measures an early stage of
information processing (sensorimotor gating). It is less clear whether these information
processing deficits extend to prepulse facilitation (PPF), which measures a later stage of
generalized alerting or orienting. METHODS: This study examined three separate issues:
first, whether schizophrenia patients have deficits in PPI and PPF; second, whether the …
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