Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene
CY Lee, SH An, I Kim, DM Go, DY Kim, JG Choi… - Scientific Reports, 2017 - nature.com
The polymerase of avian influenza A virus (AIV) is a heterotrimer composed of PB2, PB1,
and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites
for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated.
Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-
pathogenic traits to a PR8-derived recombinant virus when it was used to infect mice. Here,
we demonstrated that key amino acid mutations (I66M, I109V, and I133V, collectively …
and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites
for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated.
Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-
pathogenic traits to a PR8-derived recombinant virus when it was used to infect mice. Here,
we demonstrated that key amino acid mutations (I66M, I109V, and I133V, collectively …
Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.
LCY Lee ChungYoung, ASH An SeHee… - 2017 - cabidigitallibrary.org
The polymerase of avian influenza A virus (AIV) is a heterotrimer composed of PB2, PB1,
and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites
for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated.
Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-
pathogenic traits to a PR8-derived recombinant virus when it was used to infect mice. Here,
we demonstrated that key amino acid mutations (I66 M, I109V, and I133V, collectively …
and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites
for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated.
Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-
pathogenic traits to a PR8-derived recombinant virus when it was used to infect mice. Here,
we demonstrated that key amino acid mutations (I66 M, I109V, and I133V, collectively …
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