The presence of an ApoE ε4 allele (ε4+) increases the risk of developing Alzheimer's
disease (AD). Previous studies support an adverse relationship between ε4+ status and
brain structure and function in mild cognitive impairment and AD; in contrast, the presence of
an ε2 allele may be protective. Whether these findings reflect disease-related effects or pre-
existing endophenotypes, however, remains unclear. The present study examined the
influence of ApoE allele status on brain structure solely during middle-age in a large …

The presence of an ApoE ℇ4 allele (ℇ4+) increases the risk of developing Alzheimer's
disease (AD). Previous studies support an adverse relationship between ℇ4+ status and
brain structure and function in mild cognitive impairment and AD; in contrast, the presence of
an ℇ2 allele may be protective. Whether these findings reflect disease-related effects or pre-
existing endophenotypes, however, remains unclear. The present study examined the
influence of ApoE allele status on brain structure solely during middle-age in a large …