[HTML][HTML] Presynaptic effects of muscarine on ACh release at the frog neuromuscular junction
I Slutsky, H Parnas, I Parnas - The Journal of physiology, 1999 - ncbi.nlm.nih.gov
I Slutsky, H Parnas, I Parnas
The Journal of physiology, 1999•ncbi.nlm.nih.gov… In the present study, we investigated the muscarinic regulation of ACh release at the frog
neuromuscular junction (NMJ) and found that muscarine had a dual effect, causing both
inhibition and enhancement of release. The level of both effects depended on the amplitude of
the depolarizing pulse administered to the presynaptic terminal. A stronger inhibitory … Similar
to the observation of Katz & Miledi (1977) that curare produced postsynaptic hyperpolarization,
our finding that atropine increased the basic level of release suggests a tonic presynaptic …
neuromuscular junction (NMJ) and found that muscarine had a dual effect, causing both
inhibition and enhancement of release. The level of both effects depended on the amplitude of
the depolarizing pulse administered to the presynaptic terminal. A stronger inhibitory … Similar
to the observation of Katz & Miledi (1977) that curare produced postsynaptic hyperpolarization,
our finding that atropine increased the basic level of release suggests a tonic presynaptic …
Abstract
1. Presynaptic effects of muscarine on neurotransmitter release were studied at the frog neuromuscular junction, using focal depolarization of the presynaptic terminal to different levels.
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