Secondary infections are the most common complications in patients suffering from tuberculosis. The present study was conducted to evaluate the prevalence of secondary infections caused by Pseudomonas species among pulmonary tuberculous patients. The antibiotic resistance pattern of these isolates was also determined. The Clinical specimens were collected from 510 hospitalized tuberculous patients and were processed for isolation and identification of Pseudomonas species by using standard diagnostic criteria. The Pseudomonas species were isolated from 12.0%(61/510) specimens. Among these species, the incidence of P. aeruginosa was highest ie, 9.6%(49/510). The incidences of other Pseudomonas species were noted as P. acidovorans (0.3%), P. alcaligenes (1%), P. diminuta (0.6%), P. mallei (0.3%) and P. pseudoalcaligenes (0.4%). Emergence of multidrug resistance among these species was noted against most of the broad spectrum antibiotics used in the present study such as Penicillin derivatives, Cephalosporins of first and second generation and Tetracyclines. The results of present study highlight the importance of prompt management of such patients.