This research aims to determine the effectiveness of using a local social organizations to prevent the spread of HIV/AIDS on fishermen community in Jember. The method used in this study is action research. The research respondents consist of 40 members of Islamic study group, 38 members of gathering, 47 members of community were selected by purposive sampling. The research data were obtained through questionnaires, observation, in-depth interviews and focus group discussions, while the analysis of the data using descriptive statistics. This research showed that local social organizations effectively used for the prevention of the spread of HIV/AIDS on fishermen community.