Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink
C Wenus, R Goll, EB Loken, AS Biong… - European journal of …, 2008 - nature.com
C Wenus, R Goll, EB Loken, AS Biong, DS Halvorsen, J Florholmen
European journal of clinical nutrition, 2008•nature.comObjective: To study the preventive effect of a milk drink fermented with multistrain probiotics
on antibiotic associated diarrhoea (AAD). Design: Double-blind placebo controlled study.
Setting: University Hospital of North Norway. Subjects and methods: Of 853 patients treated
with antibiotics, 87 met the inclusion criteria, and were randomized to ingestion of a
fermented milk drink containing LGG, La-5 and Bb-12 (n= 46) or placebo with heat-killed
bacteria (n= 41), during a period of 14 days. A diary was recorded, and stool samples were …
on antibiotic associated diarrhoea (AAD). Design: Double-blind placebo controlled study.
Setting: University Hospital of North Norway. Subjects and methods: Of 853 patients treated
with antibiotics, 87 met the inclusion criteria, and were randomized to ingestion of a
fermented milk drink containing LGG, La-5 and Bb-12 (n= 46) or placebo with heat-killed
bacteria (n= 41), during a period of 14 days. A diary was recorded, and stool samples were …
Abstract
Objective:
To study the preventive effect of a milk drink fermented with multistrain probiotics on antibiotic associated diarrhoea (AAD).
Design:
Double-blind placebo controlled study.
Setting:
University Hospital of North Norway.
Subjects and methods:
Of 853 patients treated with antibiotics, 87 met the inclusion criteria, and were randomized to ingestion of a fermented milk drink containing LGG, La-5 and Bb-12 (n= 46) or placebo with heat-killed bacteria (n= 41), during a period of 14 days. A diary was recorded, and stool samples were collected for microbiological analyses.
Results:
Sixty-three patients completed the study according to the protocol; two patients (5.9%) in the treatment group and eight (27.6%) in the placebo group developed AAD (P= 0.035). The relative risk of developing AAD was 0.21 (95% confidence interval: 0.05–0.93) when given probiotic milk drink.
Conclusion:
A fermented multistrain probiotic milk drink may prevent four of five cases of AAD in adult hospitalized patients.
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