Introduction: The diagnosis of primary giant cell-rich lesion of bone is often difficult even for experienced pathologist. The diagnostic histological features are: multinucleated osteoclast-like giant cell and a mononuclear stroma. But sometimes, from the histological picture alone, it is difficult to differentiate between different lesions such as a Giant-cell tumour of bone, Aneurysmal Bone Cyst and Giant-cell Reparative Granuloma. Many of these lesions show some characteristic features such as typical anatomic location and age of the patient, which are also important supporting factor for diagnosis. Hence histopathological study with clinico-radiological correlation is mandatory for precise and accurate diagnosis. These parameters are important for the treatment and prognosis of these lesions.

Aims & objective: Aims of the study were, to study Histopathology of Primary Giant cell-rich lesion of bone, to study the clinico-radiological correlation in these lesions & to study the diagnostic utility of findings these lesions.

Material & method: In the present study, we have retrospectively examined 50 cases of primary giant-cell rich lesions of bone using biopsy tissue and large resected tissue material. All patients were diagnosed and treated at our institute from 1/10/2013 to 30/9/2014. Patients’ details, Clinical Examination, Histopathological Examination, Radiological details were studied and correlated.

Result & conclusion: Common lesions under this category were Giant Cell Tumour of Bone (41), Aneurysmal Bone Cyst (04), Giant Cell-Rich Osteosarcoma (02), Giant Cell Reparative Granuloma (02), and Fibrous Dysplasia (01). Detailed Histopathological study and clinic-radiological correlation is very helpful to arrive at precise and accurate diagnosis. This in turn, is very helpful for precise treatment of these patients and to know the prognosis of these patients.