Primary mouse lung fibroblasts help macrophages to tackle Mycobacterium tuberculosis more efficiently and differentiate into myofibroblasts up on bacterial …
SC Verma, P Agarwal, MY Krishnan - Tuberculosis, 2016 - Elsevier
Keeping with their classical role in wound healing, fibroblasts of the lung take part in the
resolution of tubercular granulomas. They are totally absent in nascent granulomas, but
surround necrotizing granulomas, and are the majority of cells in healed granulomas. Lung
fibroblasts may become infected with Mycobacterium tuberculosis (Mtb). Two previous
studies suggested an immunomodulatory effect of fibroblasts on infected macrophages. In
the present study, we looked at the role of primary mouse lung fibroblasts on naive or …
resolution of tubercular granulomas. They are totally absent in nascent granulomas, but
surround necrotizing granulomas, and are the majority of cells in healed granulomas. Lung
fibroblasts may become infected with Mycobacterium tuberculosis (Mtb). Two previous
studies suggested an immunomodulatory effect of fibroblasts on infected macrophages. In
the present study, we looked at the role of primary mouse lung fibroblasts on naive or …
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