Production and characterization of monoclonal antibodies against different epitopes of Ebola virus antigens
S Shahhosseini, D Das, X Qiu, H Feldmann… - Journal of virological …, 2007 - Elsevier
Ebola virus (EBOV) causes hemorrhagic fever in humans and nonhuman primates with up to
90% mortality rate. In this study, Ebola virus like particles (EVLPs) and the aglycosyl
subfragment of glycoprotein (GP1 subfragment D) were used to generate monoclonal
antibodies (MAbs) against different epitopes of the viral antigens. Such MAbs could be
useful in diagnostics and potential therapeutics of viral infection and its hemorrhagic
symptoms. Hybridoma cell fusion technology was used for production of MAbs. The MAbs …
90% mortality rate. In this study, Ebola virus like particles (EVLPs) and the aglycosyl
subfragment of glycoprotein (GP1 subfragment D) were used to generate monoclonal
antibodies (MAbs) against different epitopes of the viral antigens. Such MAbs could be
useful in diagnostics and potential therapeutics of viral infection and its hemorrhagic
symptoms. Hybridoma cell fusion technology was used for production of MAbs. The MAbs …
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