Monoterpenes (C10 isoprenoids) are the main components of essential oils and are
possible precursors for many commodity chemicals and high energy density fuels.
Monoterpenes are synthesized from geranyl diphosphate (GPP), which is also the precursor
for the biosynthesis of farnesyl diphosphate (FPP). FPP biosynthesis diverts the carbon flux
from monoterpene production to C15 products and quinone biosynthesis. In this study, we
tested a chromosomal mutation of Escherichia coli's native FPP synthase (IspA) to improve …

Monoterpenes (C 10 isoprenoids) are the main components of essential oils and used as
precursors for the synthesis of commodity chemicals and high energy density fuels. Plants
are major source of these monoterpenes and recently microbial production of monoterpenes
has been explored to be a promising alternative. Heterologous expression of the
mevalonate (MVA) pathway and several monoterpene synthases in E. coli led to the
production of various monoterpenes, but in general, the titer of microbial monoterpene …