Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2
Kainic acid (KA)-induced seizure in rat involves eicosanoid production in the brain, but their
production mechanism and biological functions are poorly understood. We profiled the
eicosanoid production during KA-induced seizure by a comprehensive lipidomics analysis
using liquid chromatography-tandem mass spectrometry. Systemic KA administration
caused production of large amounts of prostaglandin (PG) F 2α and PGD 2 in the
hippocampus, with smaller amounts of other PGs and hydroxyeicosatetraenoic acids. The …
production mechanism and biological functions are poorly understood. We profiled the
eicosanoid production during KA-induced seizure by a comprehensive lipidomics analysis
using liquid chromatography-tandem mass spectrometry. Systemic KA administration
caused production of large amounts of prostaglandin (PG) F 2α and PGD 2 in the
hippocampus, with smaller amounts of other PGs and hydroxyeicosatetraenoic acids. The …
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