Prolactin level is significantly elevated in lesional skin of patients with psoriasis

EA El‐Khateeb, NM Zuel‐Fakkar… - International journal …, 2011 - Wiley Online Library
EA El‐Khateeb, NM Zuel‐Fakkar, SM Eid, SE Abdul‐Wahab
International journal of dermatology, 2011•Wiley Online Library
Background Accumulating data point to a potential role of prolactin in the pathogenesis of
psoriasis. Methods We initiated a study including psoriasis patients (n= 15) and healthy
volunteers (n= 15) as controls. Psoriasis area and severity index (PASI) score was
evaluated, and prolactin levels in serum and blister fluid were assessed by enzyme‐linked
immunosorbent assay (ELISA). Results Prolactin levels were significantly (P< 0.01) elevated
in blister fluid of psoriatic lesional skin. Correlations between PASI score and different serum …
Abstract
Background  Accumulating data point to a potential role of prolactin in the pathogenesis of psoriasis.
Methods  We initiated a study including psoriasis patients (n = 15) and healthy volunteers (n = 15) as controls. Psoriasis area and severity index (PASI) score was evaluated, and prolactin levels in serum and blister fluid were assessed by enzyme‐linked immunosorbent assay (ELISA).
Results  Prolactin levels were significantly (P < 0.01) elevated in blister fluid of psoriatic lesional skin. Correlations between PASI score and different serum prolactin levels in lesional and non‐lesional skin were insignificant. Significant positive correlations of prolactin level were observed between lesional and non‐lesional skin in psoriasis (P < 0.05) and between serum and clinically normal skin in both psoriasis and control subjects (P < 0.05).
Conclusions  Locally produced prolactin may be involved in the pathogenesis of psoriatic lesions.
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