[HTML][HTML] Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding
S Han, S Okawa, GA Wilkinson, H Ghazale, L Adnani… - Neuron, 2021 - cell.com
Asymmetric neuronal expansion is thought to drive evolutionary transitions between
lissencephalic and gyrencephalic cerebral cortices. We report that Neurog2 and Ascl1
proneural genes together sustain neurogenic continuity and lissencephaly in rodent
cortices. Using transgenic reporter mice and human cerebral organoids, we found that
Neurog2 and Ascl1 expression defines a continuum of four lineage-biased neural progenitor
cell (NPC) pools. Double+ NPCs, at the hierarchical apex, are least lineage restricted due to …
lissencephalic and gyrencephalic cerebral cortices. We report that Neurog2 and Ascl1
proneural genes together sustain neurogenic continuity and lissencephaly in rodent
cortices. Using transgenic reporter mice and human cerebral organoids, we found that
Neurog2 and Ascl1 expression defines a continuum of four lineage-biased neural progenitor
cell (NPC) pools. Double+ NPCs, at the hierarchical apex, are least lineage restricted due to …
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