Proteases and delayed wound healing

SM McCarty, SL Percival - Advances in wound care, 2013 - liebertpub.com
… key roles of proteases in wound healing. It … protease expression within the wound environment
and the ways in which excessive protease expression and activation can lead to a delay

The detrimental impact of extracellular bacterial proteases on wound healing

S Lindsay, A Oates, K Bourdillon - International wound journal, 2017 - Wiley Online Library
proteases can negatively impact the wound environment, leading to delayed wound healing.
… extracellular bacterial proteases; review the impact they have on the wound environment, …

… role of endogenous and exogenous enzymes in chronic wounds: a focus on the implications of aberrant levels of both host and bacterial proteases in wound healing

SM McCarty, CA Cochrane, PD Clegg… - Wound Repair and …, 2012 - Wiley Online Library
… relationship between unregulated levels of both host and bacterial proteases and delayed
wound healing. Cutaneous wound healing is the result of a complex process of physiological …

Protease activity as a prognostic factor for wound healing in complex wounds

MJ Westby, G Norman, REB Watson… - Wound Repair and …, 2020 - Wiley Online Library
Proteases may persist longer in nonhealing wounds. We sought to investigate whether
protease activity, protease … prognostic factors for healing of complex wounds. We searched …

Proteases in wound healing and immunity

N Singh, D Bhattacharyya - Proteases in human diseases, 2017 - Springer
… in wound care established several means to control the level of proteases, such as MMP
modulators including protease-… Besides wound healing, proteases also play a significant role in …

Proteolytic enzymes in wound healing: the role of enzymatic debridement

RD Sinclair And, TJ Ryan - Australasian journal of dermatology, 1994 - Wiley Online Library
… of freely available proteolytic enzymes for wound dressings, … these proteolytic enzymes are
useful in making wounds heal … and possibly also in wound healing can be through lymphatic …

Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy

M Gao, TT Nguyen, MA Suckow… - Proceedings of the …, 2015 - National Acad Sciences
… To test the hypothesis that MMP-8 contributes to the repair in diabetic wound healing, we
evaluated the effect of topical application of the protease MMP-8 to wounds of db/db mice. We …

Proteinases in cutaneous wound healing

M Toriseva, VM Kähäri - Cellular and Molecular Life Sciences, 2009 - Springer
… As growth factors and cytokines regulate the expression of proteases by various cell types
involved in wound healing, active proteases regulate the bioavailability of a variety of soluble …

Protease activity as a prognostic factor for wound healing in venous leg ulcers

MJ Westby, JC Dumville, N Stubbs… - Cochrane Database …, 2018 - cochranelibrary.com
… down proteins and which may affect wound healing. We wanted to know whether having
higher protease levels meant that wounds were less likely to heal or to heal more slowly. If so, …

Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors

NJ Trengove, MC Stacey, S Macauley… - Wound Repair and …, 1999 - Wiley Online Library
… role of proteases in normal wound healing but the levels and duration of protease expression
is … These functions are essential during the normal wound healing process, however, it is …