Protection of the myocardium against ischemia/reperfusion injury by punicalagin through an SIRT1-NRF-2-HO-1-dependent mechanism
LM Yu, X Dong, XD Xue, J Zhang, Z Li, HJ Wu… - Chemico-Biological …, 2019 - Elsevier
Punicalagin has been found to exert cardiac protective effects against myocardial
ischemia/reperfusion (MI/R) injury, although the detailed mechanisms remain largely
unknown. This experiment was performed to explore the potential involvement of silent
information regulator 1 (SIRT1)-NFE2-related factor 2 (NRF-2)-heme oxygenase-1 (HO-1)
pathway in the cardiac protective actions of punicalagin. Sprague-Dawley (SD) rats were
subjected to MI/R operation with or without punicalagin treatment (40 mg kg− 1 d− 1). We …
ischemia/reperfusion (MI/R) injury, although the detailed mechanisms remain largely
unknown. This experiment was performed to explore the potential involvement of silent
information regulator 1 (SIRT1)-NFE2-related factor 2 (NRF-2)-heme oxygenase-1 (HO-1)
pathway in the cardiac protective actions of punicalagin. Sprague-Dawley (SD) rats were
subjected to MI/R operation with or without punicalagin treatment (40 mg kg− 1 d− 1). We …
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