TMK-801 is an antagonist of N-methyl-D-aspartate (NMDA) receptors. Sub-chronic administration of 1 mg/kg dose of MK-801 resulted in schizophrenia-like symptoms and degeneration in the brain of mice. In this study, it was investigated whether this dose could cause histopathological changes in kidney and liver tissues and resveratrol had a protective role against these changes. For this aim, 24 male mice were obtained and divided equally into 4 groups. The animals in the control group were intraperitoneally (ip) given 10 mL/kg saline solution, the animals in the experiment groups were ip given 1 mg/kg MK-801 alone, 40 mg/kg resveratrol alone and MK-801 by 1 mg/kg for 14 days. The kidney and the liver of the sacrificed mice were collected and routine histology procedure was applied. Glomerular shrinkage was observed in the kidneys after the measurements. Besides this finding, histopathological changes were observed in both kidney and liver tissue and resveratrol inhibited most of the harmful effects. In conclusion, MK-801 caused histopathological changes in both kidney and liver tissues, and resveratrol had a significantly protective role on this injury.