Protective effect of the hydroalcoholic extract from Lampaya medicinalis Phil.(Verbenaceae) on palmitic acid-impaired insulin signaling in 3T3-L1 adipocytes
P Ormazabal, K Herrera, M Cifuentes, A Paredes… - Obesity Research & …, 2020 - Elsevier
Background Obesity is strongly associated with insulin resistance (IR). IR at the molecular
level may be defined as a diminished activation of insulin signaling-related molecules (IRS-
1/Akt/AS160) as well as reduced glucose uptake. Subject with obesity have elevated plasma
levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin signaling
disruption in vivo and in vitro. Infusions of Lampaya medicinalis Phil.(Verbenaceae) are
used in folk medicine of Northern Chile to counteract inflammatory diseases. Hydroethanolic …
level may be defined as a diminished activation of insulin signaling-related molecules (IRS-
1/Akt/AS160) as well as reduced glucose uptake. Subject with obesity have elevated plasma
levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin signaling
disruption in vivo and in vitro. Infusions of Lampaya medicinalis Phil.(Verbenaceae) are
used in folk medicine of Northern Chile to counteract inflammatory diseases. Hydroethanolic …
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