Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells
β-Amyloid (Aβ) peptide is the major component of senile plaques and is considered to have
a causal role in the development and progression of Alzheimer's disease (AD). There is
compelling evidence supporting the notion that Aβ-induced cytotoxicity is mediated though
the generation of ROS. In the present study, we investigated the neuroprotective effects of
ursolic acid (UA), p-coumaric acid (p-CA), and gallic acid (GA) isolated from Corni fructus
(CF) against Aβ (25–35)-induced toxicity in PC12 cell. Exposure of PC12 cells to 50 μM Aβ …
a causal role in the development and progression of Alzheimer's disease (AD). There is
compelling evidence supporting the notion that Aβ-induced cytotoxicity is mediated though
the generation of ROS. In the present study, we investigated the neuroprotective effects of
ursolic acid (UA), p-coumaric acid (p-CA), and gallic acid (GA) isolated from Corni fructus
(CF) against Aβ (25–35)-induced toxicity in PC12 cell. Exposure of PC12 cells to 50 μM Aβ …
Protective effects of the key compounds isolated from Corni fructus against β-Amyloid-induced neurotoxicity in PC12 cells.
HSY Hong SeungYoung, JWS Jeong WooSik… - 2012 - cabidigitallibrary.org
Abstract β-Amyloid (Aβ) peptide is the major component of senile plaques and is considered
to have a causal role in the development and progression of Alzheimer's disease (AD).
There is compelling evidence supporting the notion that Aβ-induced cytotoxicity is mediated
though the generation of ROS. In the present study, we investigated the neuroprotective
effects of ursolic acid (UA), p-coumaric acid (p-CA), and gallic acid (GA) isolated from Corni
fructus (CF) against Aβ (25-35)-induced toxicity in PC12 cell. Exposure of PC12 cells to 50 …
to have a causal role in the development and progression of Alzheimer's disease (AD).
There is compelling evidence supporting the notion that Aβ-induced cytotoxicity is mediated
though the generation of ROS. In the present study, we investigated the neuroprotective
effects of ursolic acid (UA), p-coumaric acid (p-CA), and gallic acid (GA) isolated from Corni
fructus (CF) against Aβ (25-35)-induced toxicity in PC12 cell. Exposure of PC12 cells to 50 …
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