Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo
AV Emelyanov, AY Konev, E Vershilova… - Journal of Biological …, 2010 - ASBMB
ATRX belongs to the family of SWI2/SNF2-like ATP-dependent nucleosome remodeling
molecular motor proteins. Mutations of the human ATRX gene result in a severe genetic
disorder termed X-linked α-thalassemia mental retardation (ATR-X) syndrome. Here we
perform biochemical and genetic analyses of the Drosophila melanogaster ortholog of
ATRX. The loss of function allele of the Drosophila ATRX/XNP gene is semilethal.
Drosophila ATRX is expressed throughout development in two isoforms, p185 and p125 …
molecular motor proteins. Mutations of the human ATRX gene result in a severe genetic
disorder termed X-linked α-thalassemia mental retardation (ATR-X) syndrome. Here we
perform biochemical and genetic analyses of the Drosophila melanogaster ortholog of
ATRX. The loss of function allele of the Drosophila ATRX/XNP gene is semilethal.
Drosophila ATRX is expressed throughout development in two isoforms, p185 and p125 …
以上显示的是最相近的搜索结果。 查看全部搜索结果