Okadaic acid (OA) is a protein phosphatase (PP) inhibitor and induces
hyperphosphorylation of p53. We investigated whether the inhibition of PP1 by OA promotes
the phosphorylation of the serine 15 of p53. In vitro dephosphorylation assay showed that
PP1 dephosphorylated ultraviolet C (UVC)‐induced phospho‐ser15 of p53, and that OA
treatment inhibited it. One of the PP1 regulators, growth arrest and DNA damage 34
(GADD34), disturbed PP1 binding with p53, interfered with the dephosphorylation of p53 …

CiNii 博士論文 - Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates
DNA-damaging stress-induced phospho-serine 15 of p53 … Protein phosphatase 1, but not
protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of
p53 DNA障害性ストレスによるp53のリン酸化セリン15位を脱リン酸化するのはプロテインフォスファターゼ
2Aではなくプロテインフォスファターゼ1である … Protein phosphatase 1, but not protein
phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53 …