Proteomic analysis reveals that the Rab GTPase RabE1c is involved in the degradation of the peroxisomal protein receptor PEX7 (peroxin 7)
The biogenesis of peroxisomes is mediated by peroxins (PEXs). PEX7 is a cytosolic receptor
that imports peroxisomal targeting signal type 2 (PTS2)-containing proteins. Although PEX7
is important for protein transport, the mechanisms that mediate its function are unknown. In
this study, we performed proteomic analysis to identify PEX7-binding proteins using
transgenic Arabidopsis expressing green fluorescent protein (GFP)-tagged PEX7. Our
analysis identified RabE1c, a small GTPase, as a PEX7 binding partner. In vivo analysis …
that imports peroxisomal targeting signal type 2 (PTS2)-containing proteins. Although PEX7
is important for protein transport, the mechanisms that mediate its function are unknown. In
this study, we performed proteomic analysis to identify PEX7-binding proteins using
transgenic Arabidopsis expressing green fluorescent protein (GFP)-tagged PEX7. Our
analysis identified RabE1c, a small GTPase, as a PEX7 binding partner. In vivo analysis …
Proteomic analysis reveals that the Rab GTPase RabE1c is involved in the degradation of the peroxisomal protein receptor PEX7 (Peroxin 7).
CSK Cui SongKui, Y Fukao, S Mano, K Yamada… - 2013 - cabidigitallibrary.org
The biogenesis of peroxisomes is mediated by peroxins (PEXs). PEX7 is a cytosolic receptor
that imports peroxisomal targeting signal type 2 (PTS2)-containing proteins. Although PEX7
is important for protein transport, the mechanisms that mediate its function are unknown. In
this study, we performed proteomic analysis to identify PEX7-binding proteins using
transgenic Arabidopsis expressing green fluorescent protein (GFP)-tagged PEX7. Our
analysis identified RabE1c, a small GTPase, as a PEX7 binding partner. In vivo analysis …
that imports peroxisomal targeting signal type 2 (PTS2)-containing proteins. Although PEX7
is important for protein transport, the mechanisms that mediate its function are unknown. In
this study, we performed proteomic analysis to identify PEX7-binding proteins using
transgenic Arabidopsis expressing green fluorescent protein (GFP)-tagged PEX7. Our
analysis identified RabE1c, a small GTPase, as a PEX7 binding partner. In vivo analysis …
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