Multiple myeloma (MM) is a hematological malignancy of clonal plasma cells in the bone
marrow (BM). The microenvironment plays a key role in MM cell survival and drug resistance
through release of soluble factors, expression of adhesion molecules and release of
extracellular vesicles (EVs). The aim of this manuscript is to use proteomic profiling of EVs
as a tool to identify circulating tumor associated markers in MM patients. First, we
characterized the EV protein content obtained from different MM cell lines. Then, we …

Introduction: Multiple myeloma (MM) is a hematological malignancy of clonal plasma cells
(PCs) in the bone marrow (BM). MM cells are dependent on the BM microenvironment (eg
BM stromal cells, macrophages etc) and create a network with surrounding cells. These cells
play a pivotal role in the regulation of MM cell survival and drug resistance bydirect
interactions through adhesion molecules causing cell adhesion mediated drug resistance
(CAM-DR) or soluble factors including supportive cytokines (eg IL-6, IL-8, and VEGF) or …