Posttraumatic Stress Disorder (PTSD) is one of the most common, chronic and debilitating disorders. The present research was conducted to determine the psychometric properties of the Persian version of the PTSD Checklist for DSM-5 (PCL-5). The research method is descriptive and correlational. Sampling method is convenience. Sample size in the first step consists of 201 people and the final step includes validated questionnaires including 157 Tehran citizens who have experienced excessive stress and from April to September 2017 responded to the Connor- Davidson Resilience Scale (CD-RISC) and the PTSD scale of MCCP (MCCP). The results of exploratory factor analysis showed that PCL-5 has a five-factor structure in Iranian culture. The internal consistency of the scale is high and the Cronbach's alpha is equal to 0.92. Significant correlation between the scores of this scale and the MCCP scores indicates the desired convergent validity (0.74) and with the CD-RISC scores represent a desirable divergent validity (0.46). PCL-5 as a tool according to DSM-5 can help specialists in the assessment of PTSD.