resulted in various on-line botanical companies advertising and selling S. divinorum as a
legal alternative to other regulated plant hallucinogens. It is predictable that its misuse will
increase rapidly. The active ingredient in S. divinorum is the neoclerodane diterpene,
salvinorin A (1a), which has been shown to be a κ agonist both in vitro and in vivo. This
review will cover the current state of research into the psychopharmacology of S. divinorum.