Pulmonary administration of biodegradable drug nanocarriers for more efficacious treatment of fungal infections in lungs: Insights based on recent findings
Lung fungal infection is a critical health problem, particularly in immunocompromised
patients suffering from lung cancer, cystic fibrosis, HIV infection, etc. Due to rapid blood
turnover in lungs, conventional drug delivery systems do not offer persistent blood level of
drug in the lungs, causing inadequate drug bioavailability locally. Hence, a large amount of
dose is generally required for a prolonged period, causing toxicity. The patients, therefore,
cannot tolerate the treatment, and recurrence of fungal infection by the fungal spores may …
patients suffering from lung cancer, cystic fibrosis, HIV infection, etc. Due to rapid blood
turnover in lungs, conventional drug delivery systems do not offer persistent blood level of
drug in the lungs, causing inadequate drug bioavailability locally. Hence, a large amount of
dose is generally required for a prolonged period, causing toxicity. The patients, therefore,
cannot tolerate the treatment, and recurrence of fungal infection by the fungal spores may …
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