We fabricated a hybrid bulk heterojunction (BHJ) photovoltaic devices composed of pyridine-coated lead sulfide (PbS-py) quantum dots (QDs) and poly-3-hexylthophene (P3HT). The selection of PbS QDs was based on the magnitude of their bandgaps (∼1.1–1.4 eV), allowing absorption of near infrared region of the spectrum. The pyridine coatings of the QDs proved crucial for their interfacial charge-transduction properties. In comparison with traditionally employed oleate agents, using pyridine coatings allowed us to observe photoinduced electron transfer from the polymer to the QDs. Incorporation of optimized amount of PbS QDs in the BHJ, resulted an enhancement of the power conversion efficiency that was as high as 170% (under AM 1.5G, 1 sun illumination) in comparison with analogous devices containing solely P3HT in their active layers.